Present situation of rational drug use in plateau area

Abstract Plateau is characterized by low oxygen, pressure, strong radiation, cold and dryness, among which oxygen the main factor that affects normal life activities of human body. Altitude hypoxia leads to significant changes in metabolic characteristics drugs vivo , turn efficacy adverse actions drugs. This paper summarizes present situation rational drug use plateau area pinpoints existing problems. Meanwhile, we posit strategies measures for realizing precise pharmacotherapy residents. First, need acquire a panoramic view differential relative pharmacokinetics pharmacodynamics between plain carrying out comparative studies on metabolisms comprehensive efficacies mechanisms. Second, must apply findings from basic research clinical practice formulate guidelines recommendations habitants. Finally, should eventually achieve individualized habitants based their characteristic etiology pathogenesis.